Abstract
A phytochemical study of the aerial parts of Euphorbia neriifolia led to the isolation of six new ingenane-type diterpenoids, phonerilins A–F (1–6), five new ingol-type diterpenoids, phonerilins G–K (7–11), and five known analogues (12–16). Their structures with absolute configurations were elucidated by a combined method. Phonerilin A (1) is the second rearranged ingenane diterpenoid with a unique 6/6/7/3-fused ring system. Based on single-crystal X-ray diffraction and NOESY data, the structure of 20-deoxy-16-hydroxyingenol was revised as 20-deoxy-17-hydroxyingenol (12) that is likely the biogenetic precursor of 1. Biological evaluation revealed some isolates exhibited cytotoxic effects against two human tumor cell lines, A549 and HL-60.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
