Abstract
Background: A.baumannii is an important emerging human pathogen and is among one of the important pathogens causing hospital acquired infections as well as community infections. The present study was conducted with the aim to know resistance pattern of A.baumannii and to detect the production of Metallo beta lactamase enzyme in Carbapenem resistant A.baumanni. Material and Methods: During six months prospective study, all isolates of Acinetobacter obtained from various clinical samples like respiratory, pus, blood and others were included. Antimicrobial susceptibility testing was done by Vitek 2 compact system. MBL detection was done phenotypically by imipenem-EDTA combined disk method. Results: Out of 1336 culture positive samples, 146 isolates were of A.baumannii. Majority of the isolates were isolated from ET tubes/ ET secretions (45.27%). A.baumannii isolates were highly resistant towards various antimicrobials tested including, carbapenems. However isolates of A.baumanniishowed high level of sensitive towards Colistin (94.2%) and Minocycline (82.2%). Out of total 124 carbapenem resistant isolates of A.baumannii MBLproduction was observed in (86.2%) isolates. Conclusion: In the present study high rate of resistance was observed towards most of the antimicrobials tested. The present study also revealed high proportion of MBL producing Acinetobacter baumannii. Therefore early detection and infection control practices are the best defenses against these organisms; therefore, systematic surveillance to detect MBLproducers is necessary. It is most important to follow antibiotic restriction policies to avoid excessive use of carbapenem and other broad spectrum antibiotics in order to prevent going towards the era with no antibiotics.
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