Abstract
A phytochemical study on the aerial parts of Mikania micrantha led to the isolation of two new phenolic compounds, benzyl 5-O-β-d-glucopyranosyl-2,5-dihydroxybenzoate (1) and (7S,8R)-threo-dihydroxydehydrodiconiferyl alcohol 9-acetate (2), together with twelve known compounds, benzyl 2-O-β-d-glucopyranosyl-2,6-dihydroxybenzoate (3), 4-allyl-2,6-dimethoxyphenol glucoside (4), (+)-isolariciresinol (5), icariol A2 (6), 9,10-dihydroxythymol (7), 8,9,10-trihydroxythymol (8), caffeic acid (9), p-coumaric acid (10), ethyl protocatechuate (11), procatechuic aldehyde (12), 4-hydroxybenzoic acid (13), and hydroquinone (14). Their structures were elucidated on the basis of extensive spectroscopic analysis. Except 8 and 9, all the other compounds were isolated from this plant species for the first time. The antioxidant activity of those isolated compounds were evaluated using three different assays. Compounds 1, 2, 3, 9, 10, 13, and 14 demonstrated significant 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) free radical cation scavenging activity ranging from SC50 0.31 to 4.86 µM, which were more potent than l-ascorbic acid (SC50 = 10.48 µM). Compounds 5, 9, 11, and 12 exhibited more potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (SC50 = 16.24–21.67 µM) than l-ascorbic acid (39.48 µM). Moreover, the ferric reducing antioxidant power (FRAP) of compounds 2, 5, 9, and 11 were discovered to be also comparable to or even more potent than l-ascorbic acid.
Highlights
IntroductionB. K., belonging to the Asteraceae family, is a fast-growing perennial creeping vine indigenous to Central and South America
Nuclear magnetic resonance (NMR) spectra were recorded on a Bruker DRX-500 NMR spectrometer (Bruker Biospin Gmbh, Rheistetten, Germany)
Fourteen phenolic compounds, including two new ones—1 and 2, were isolated from the aerial parts of M. micrantha. Their structures were identified by analysis of their spectroscopic data
Summary
B. K., belonging to the Asteraceae family, is a fast-growing perennial creeping vine indigenous to Central and South America. K., belonging to the Asteraceae family, is a fast-growing perennial creeping vine indigenous to Central and South America This plant is known as an invasive species in Southeast. Asia and the Pacific region, including southern China [1]. The rapid spread of M. micrantha in South. China has caused great damage to agriculture and forestry, as well as the ecological balance in invaded areas [1]. M. micrantha has long been used as a traditional herbal medicine in Jamaica to treat skin
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