Abstract
Parthenium hysterophorus is a globally recognized invasive alien weed that prominently colonizes grazing areas and cultivated lands causing adverse effect on crop production. Major allelochemicals released from parthenium include sesqueterpene lactones and phenolic acids. Among these the presence of caffeic, vanillic and ferulic acids is of industrial significance as they possess potent free radical scavenging and anticancer activities. This study reports for the first time, high total phenolic acid content (20.82 ± 0.82 mg GAE/g dry sample) in parthenium. The GC-MS analysis indicated the presence of ferulic, p-coumaric, vanillic and gallic acid as major phenolic components. Free radical scavenging activity of the phenolic acids extract gave an EC50 value 130.4 μg/ml when measured using DPPH assay. Anticancer activity of parthenium phenolic extract against A-498 (IC50 0.5237 μg/ml) and MDA-MB231 (IC50 and 0.2685 μg/ml) cancerous cell lines indicated its potential to be used as anticancer agent.
Highlights
Parthenium hysterophorus (Asteraceae) is a widely distributed invasive agricultural weed causing environmen-How to cite this paper: Panwar, R., Sharma, A.K., Dutt, D. and Pruthi, V. (2015) Phenolic Acids from Parthenium hysterophorus: Evaluation of Bioconversion Potential as Free Radical Scavengers and Anticancer Agents
The major allelochemicals present in parthenium are sesquiterpene lactones mainly parthenin and phenolics group that includes caffeic, vanillic, ferulic, chlorogenic and anisic acids which are responsible for affecting many plant species [2]
Phenolic acids extract from an agricultural weed parthenium was tested for its bioconversion as potent antioxidant and anticancer agent
Summary
Parthenium hysterophorus (Asteraceae) is a widely distributed invasive agricultural weed causing environmen-How to cite this paper: Panwar, R., Sharma, A.K., Dutt, D. and Pruthi, V. (2015) Phenolic Acids from Parthenium hysterophorus: Evaluation of Bioconversion Potential as Free Radical Scavengers and Anticancer Agents. As a result of their higher antioxidant potential [3], polyphenolic compounds are gaining attention across the scientific community among various medicinally important products isolated from plants They are reported to impart equivalent health benefits as are obtained from consuming rich diet comprising of fruits and vegetables [4]. This diversified group of secondary metabolites, derived from the shikimate pathway and phenylpropanoid metabolism, possesses one or more hydroxy substituted aromatic rings [5]. Owing to the broad spectrum of medical applicability of phenolics, it is necessary to obtain them from inexpensive resources In this investigation, phenolic acids extract from an agricultural weed parthenium was tested for its bioconversion as potent antioxidant and anticancer agent
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