Abstract

Nitrogen-containing compounds with cage-like fragments of norbornene, norbornane, and adamantane exhibit antiviral [1] and neurotropic [2] activity and thus are promising models for investigation of relations between the biological activity and the structure and stereochemistry of molecules. In the recent years the synthesis of these compounds is currently performed with the use of phase-transfer catalysis which plays a significant part in reactions with high sterical requirements to attacking reagents. Methods were developed for arylsulfonylation of amines [3], of alkylation and acylation of sulfonamides from the norbornene series [4].

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