Abstract
Aim to investigate changes in phase contents of bone mineral of the hipbone in pre-senile streptozotocin-induced diabetic rats after surgical perforation of the tibia.
 Material and methods. Diabetes was induced in 35 animals with an initial weight of 290-310 g at the age of 17-18 months by a single intraperitoneal injection of streptozotocin in dosage of 55 mg per kg of body weight. Surgical perforation of the tibia was modeled as 2.0 mm opening in the proximal metadiaphysis (35 animals). Another group comprised 35 animals with both perforation and diabetes. 35 intact animals comprised the control group. The content of whitlockite, calcite and hydroxylapatite in bone mineral of the hipbone was determined.
 Results. Surgical perforation of the tibia resulted in instability of phase contents of bone mineral of the hipbone by the 15th day of observation; peak of deviations was registered on the 90th day of observation, when the proportions of whitlockite and calcite increased by 7.20% and 8.91%, while the proportions of hydroxyapatite decreased by 3.53% in comparison with the controls. In diabetic animals, the destabilization of the phase composition of bone mineral was observed by the 7th day of the experiment. By the 90th day, the proportion of whitlockite and calcite exceeded those of the controls by 9.00% and 9.01% while the proportion of hydroxylapatite decreased by 4.00%. Surgical perforation of the tibia in diabetic pre-senile animals resulted in more marked increase of hipbone mineral amorphousness from the 7th day of observation; by the 90th day the proportion of whitlockite exceeded this in rats with perforation by 7.95%, while the proportion of hydroxylapatite decreased by 2.35%.
 Conclusion. Surgical perforation of the tibia in diabetic pre-senile rats results in increasing of the amorphousness of bone mineral of the hipbone, which grows starting from the 7th day after operation.
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