Abstract
This study was conducted to investigate the antiemetic, antimicrobial and anti-radical activity of methanolic extracts of Foeniculum vulgare. The antiemetic assay was carried out by using chick emetic model with minor modifications by calculating the mean decrease in the number of retching. The antimicrobial activity of the crude extract was performed by Disc Diffusion method. The anti-radical activity was determined by the 2, 2-diphenyl-2-picrylhydrazyl hydrate (DPPH) method. The anti-emetic activity of Foeniculum vulgare leaves on young chicks revealed that these extracts have a less anti-emetic effect. The group of chicks treated with Chlorpromazine was found to have 60.6 retches as compared to the 66 retches of the control group, thus Chlorpromazine reduced the retches by 7.93%. The chickens treated with leaves extracts inhibited the retches up to 2.03%. The minimum antimicrobial effect was found in this methanol crude extract. The extract did not appear potent in terms of both zones of inhibition and spectrum of activity. In anti-radical activity test, the extract showed moderate free radical scavenging activity with IC50 value 240.39μg/ml. while compared to that of the reference standard ascorbic acid. Methanolic extract of Foeniculum vulgare leaves have minimum anti-emetic and anti-microbial activities and moderate anti-radical properties.
Highlights
Nature has accomplished as a rich treasure trove of medicinal plants and a magnificent number of modern drugs have been separated from natural resources, in particular of plant origin [1]
Chick emetic model [35] was used to assay the antiemetic potency of Foeniculum vulgare with minor modifications by calculating the mean decrease in the number of retching. 2-4 days young male chicks weighing from 30-32 gm were collected from a local poultry store
Staphylococcus aureus was taken as a gram-positive organism and Escherichia coli, Pseudomonas aeruginosa, Enterobacter and Vibrio cholera were taken as gram-negative organisms
Summary
Nature has accomplished as a rich treasure trove of medicinal plants and a magnificent number of modern drugs have been separated from natural resources, in particular of plant origin [1]. Exposure to multiple drug-resistant strains of microorganisms has initiated a regenerating interest in herbal medicine due to miscellaneous use of antibiotics to handle infectious diseases [6] Plants and their derivatives have been identified with a great number of Phytochemicals having potential medicinal properties or established biological activity and used as medicine for human health since ancient times. Mature fruit or seeds of the plant and its essential oil are anise-like in the aroma, used as a flavoring agent in food products such as baked goods, liqueurs, bread, pickles, pastries, cheese, meat and fish dishes, ice cream, alcoholic beverages and herb mixtures. This present study was aimed to investigate the antiemetic, antimicrobial and anti-radical activity of methanolic extracts of Foeniculum vulgare
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