Abstract
Rats injected intraperitoneally with imidazole (100 to 400 mg/kg) showed a progressive dose-dependent decrease in rectal temperature. A decrease of 6 ° C occurred when the imidazole-treated animals were placed in a 4 ° C environment. In a 23 ° C environment, the rectal temperature declined about 2 ° C. The results show that imidazole induces a decline in body temperature in non-febrile rats, possibly due to an action on hipothalamic calcium levels.
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