Pharmacological Evaluation of Ayurvedic Nicotiana tobacum Formulation for Accelerated Wound-healing: An Experimental Study

Abstract

Background: The need for pharmacognostic-based compounds with various medicinal actions is increasing to address issues such as drug resistance, new diseases, and the toxicity of already utilized chemical compounds. The plant kingdom provides numerous bioactive molecules that have great promise to help solve these challenges, resulting in the rise of innovative solutions in the pharmaceutical sector. Ayurvedic preparations, including tobacco (Nicotiana tabacum) are considered a viable method due to their long history in herbal therapy and several medical advantages. Methods: The study aims to investigate the wound-healing properties of the tobacco plant. Tobacco leaves were utilized in the production of a traditional ayurveda formulation, which included mashi formulations such as anterdhum padhati mashi, bahirdhum padhati mashi, and muffle furnace mashi, in accordance with traditional ayurvedic methods. Aqueous and alcoholic extracts of tobacco leaves were also produced. The effectiveness of these formulations in wound-healing was evaluated using an Excision model in mice. Results: The bahirdhum padhati mashi with methanolic discharge showed significantly greater wound-healing capacity compared to a standard medication formulation, as indicated by comparative study. Conclusion: Ultimately, the bahirdhum padhati mashi made from tobacco shows potential for healing wounds and could be a useful agent for wound-healing. The results of this experimental study suggest that ayurvedic formulations could be effective in treating wound-healing difficulties. Additional research and clinical studies are needed to confirm the safety, effectiveness, and possible use in wound treatment.