Abstract
Berberine, a natural isoquinoline alkaloid, is used in herbal medicine and has recently been shown to have efficacy in the treatment of mood disorders. Furthermore, berberine modulates neurotransmitters and their receptor systems within the central nervous system. However, the detailed mechanisms of its action remain unclear. This review summarizes the pharmacological effects of berberine on mood disorders. Therefore, it may be helpful for potential application in the treatment of mood disorders.
Highlights
Mood disorders are common, chronic, recurrent mental illnesses that affect millions of individuals worldwide.[1,2] The primary mood disorders are major depressive disorder and bipolar disorder
Major depressive disorder subjects exhibited higher levels of nuclear transcription factor‐κB (NF‐κB) compared to controls.[38]
Arora et al observed a significant increase in levels of NF‐κB and caspase‐3 in the cerebral cortex and hippocampus of reserpine‐ treated rats and treatment with berberine down‐regulated the elevated levels of NF‐κB and caspase‐3.25 Chronic berberine treatment inhibited NF‐κB signalling pathway in the hippocampus and prevented the depressive deficits both in sucrose preference test and novelty‐suppressed feeding test in mice induced by chronic unpredictable mild stress.[45]
Summary
Chronic, recurrent mental illnesses that affect millions of individuals worldwide.[1,2] The primary mood disorders are major depressive disorder and bipolar disorder.
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