Abstract
The present study was undertaken to characterize the type of serotonin (5-HT) receptors involved in the control of prolactin (PRL) secretion in male rats. d-Fenfluramine (10 mg/kg i.p.), a potent 5-HT releaser and quipazine, (20 mg/kg i.p.) a 5-HT agonist, caused a marked increase in serum PRL levels. Ritanserin (200 μg/kg i.p.), a specific antagonist of 5-HT 2 receptors, administered 1 h before the administration of d-fenfluramine or quipazine, completely prevented the PRL-releasing effect of these drugs. Furthermore, the administration of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH DPAT) (1.5, 3 and 6 mg/kg i.p.), a compound considered to be a prototypical 5-HT 1A agonist, failed to induce any change in serum PRL levels. The same lack of effect on PRL secretion was observed after the administration which has been shown to possess a higher selectivity for 5-HT 1B receptor subtypes than for 5-HT 1A subtypes. These results suggest that 5-HT receptors involved in the control of PRL secretion are of the 5-HT 2 type.
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