Abstract
Obese patients gain lean and mass in different proportions to total body mass. This results in different volumes of distribution (Vd) for medications according to their lipid solubility compared to that of normal weight patients. High body mass index (BMI) patients are at increased risk of medical comorbidities that may affect drug metabolism and clearance. Anesthesiologists should factor in these differences in order to prevent erroneous medication dosing. This review contains 1 figure, 1 table, and 61 references. Keywords: obesity, induction agents, analgesics, inhaled anesthetics, neuromuscular blocking agents, reversal agents, local anesthetics, pharmacology, pharmacokinetics, pharmacodynamics
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