Abstract
Summary In a crossover trial, 7 healthy, 7- to 29-day-old, unweaned Finnish Ayrshire calves were given a single dose of 20 mg of tinidazole/kg of body weight, iv, and a single dose of 25 mg of tinidazole/kg orally. Blood samples were collected serially, and serum concentration of tinidazole was measured by use of high-performance liquid chromatography. Serum concentration vs time data were analyzed by use of the statistical moment theory. Terminal half-life was 394 minutes after iv administration and 524 minutes (harmonic mean) after oral administration. The corresponding system moment mean residence times were 542 ± 61.8 minutes and 812 ± 117 minutes (arithmetic mean ± sd), respectively. Estimated volume of distribution at steady state and total body clearance were 0.74 ± 0.05 L/kg and 1.37 ± 0.13 ml/min/kg, respectively. Tinidazole was rapidly and totally absorbed from the gastrointestinal tract. Mean absorption time was 270 ± 160 minutes, and the observed peak serum concentration was detected at 240 minutes. Bioavailability was 99.5 ± 3.9%.
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