Abstract
Intravenous anaesthetics comprise a variety of drugs that differ in chemical structure but share a suitable combination of physical properties that confer ready penetration of the blood-brain barrier. Lipid solubility is particularly important in this respect. Rapid entry into the brain is associated with rapid distribution and redistribution in the body for most of these drugs. They all readily cross the placenta to the fetus. Rate of metabolism varies between the rapidly biotransformed drugs like propanidid to the slowly metabolised ones like thiopentone. The liver is the main site of biotransformation, with the exception of propanidid which is hydrolysed by plasma pseudocholinesterase. Recovery of mental and psychomotor functions is protracted compared with inhalation anaesthetics, except after propanidid.
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