Abstract
Summary The pharmacokinetics and bioavailability of enrofloxacin were determined after iv and im administration of 5 mg/kg of body weight to 6 healthy adult rabbits. Using nonlinear least-squares regression methods, data obtained were best described by a 2-compartment open model. After iv administration, a rapid distribution phase was followed by a slower elimination phase, with a half-life of 131.5 ± 17.6 minutes. The mean body clearance rate was 22.8 ± 6.8 ml/min/kg, and the mean volume of distribution was 3.4 ± 0.9 L/kg. This large volume of distribution and the K12/K21 ratio close to 1, indicated that enrofloxacin was widely distributed in the body, but not retained in tissues. After a brief lag period (6.2 ± 2.86 min), im absorption was rapid (4.1 ± 1.3 min) and almost complete. The mean extent of im absorption was 92 ± 11%, and maximal plasma concentration of 3.04 ± 0.34 μg/ml was detected approximately 10 minutes after administration.
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