Abstract

1. Experimental human exposure of benzene and toluene: Elimination curves obtained from a single exposure in which three male subjects inhaled 25 ppm of benzene and 100 ppm of toluene for 2 hrs were graphically resolved into a sum of three exponential components; for benzene in blood, $${\text{Y = }}5.93e^{ - 0.418t} + 8.60e^{ - 0.0238t} + 2.87e^{ - 0.00317t}$$ and for toluene in blood, $${\text{Y = 3}}5.5e^{ - 0.355t} + 35.2e^{ - 0.0197t} + 12.9e^{ - 0.00339t}$$ where Y is concentration in Μg/dl and t is time in minutes from 0 to 300. 2. Solubility of benzene and toluene in various body tissues of rabbits: The tissue-blood partition coefficients for the most body tissues were in the range of 1–3. On the other hand, the solvent vapors were extremely soluble in the fat, approximately 30–50 times as much as in the blood. 3. A mathematical analysis of the transfer of benzene and toluene in a living body: Using the results described in 2., a mathematical model with regard to the absorption, distribution, metabolism and elimination of the solvent was constructed. The model could offer a possible explanation for the three-exponential decay observed in the human experimental exposure.

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