Abstract
1. Experimental human exposure of benzene and toluene: Elimination curves obtained from a single exposure in which three male subjects inhaled 25 ppm of benzene and 100 ppm of toluene for 2 hrs were graphically resolved into a sum of three exponential components; for benzene in blood, $${\text{Y = }}5.93e^{ - 0.418t} + 8.60e^{ - 0.0238t} + 2.87e^{ - 0.00317t}$$ and for toluene in blood, $${\text{Y = 3}}5.5e^{ - 0.355t} + 35.2e^{ - 0.0197t} + 12.9e^{ - 0.00339t}$$ where Y is concentration in Μg/dl and t is time in minutes from 0 to 300. 2. Solubility of benzene and toluene in various body tissues of rabbits: The tissue-blood partition coefficients for the most body tissues were in the range of 1–3. On the other hand, the solvent vapors were extremely soluble in the fat, approximately 30–50 times as much as in the blood. 3. A mathematical analysis of the transfer of benzene and toluene in a living body: Using the results described in 2., a mathematical model with regard to the absorption, distribution, metabolism and elimination of the solvent was constructed. The model could offer a possible explanation for the three-exponential decay observed in the human experimental exposure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.