Abstract
Amoxicillin, a new semisynthetic penicillin, was administered in 250‐mg doses intravenously and orally to normal men. After intravenous doses, the mean alpha disposition constant was 3.994 hr‐1 and the mean beta disposition constant was 0.692 hr‐1 with a corresponding beta half‐life of 1.05 hr. The serum clearance rate was 0.264 1.kg‐1 with a volume of distribution at steady state (Vdss) of 0.311 1.kg‐1 • The mean k. of the oral dose was 1.08 hr‐1 with a lag time of 0.34 hr. Calculation of areas under individual oral and intravenous serum concentration‐time curves indicated an absolute availability of the oral dose of 88.7% (range, 70.9 to 105.5). In comparison with ampiCillin, amoxicillin is absorbed at a faster rate and more completely from the gastro‐intestinal tract and has a larger Vdss. The beta phase half‐life and serum clearance rates of the two antibiotics are similar.
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