Abstract

Nanogels are presently the subject of a great deal of research worldwide due to their intriguing properties, such as biodegradability, biocompatibility, non-toxicity, and small size. Nanogels have great potential in biomedical and pharmaceutical fields, particularly drug delivery systems, owing to their high loading capacity, control, and targeted drug delivery. The current study aims to synthesize pH-responsive, biocompatible, chemically and physically crosslinked chitosan/polymethacrylic acid (CS/PMAA) based nanogels. FTIR study confirms the respective functional groups of CS, PMAA, and nanogels. Moreover, SEM and DLS analyses affirmed the formation of nanogels, which are submicron in size (> 200 nm and < 200 nm for 30 and 60 min reaction times, respectively). The prepared nanogels have manifested excellent stability (+ 31.66 mV and −33.12 mV, for cationic and anionic nanogels, respectively) under zeta potential measurements. The nanogels owned good thermal stability as characterized by DSC, and XRD results depict the semicrystalline structure. Cytotoxicity of prepared nanogels against PBMC cells was evaluated after 4hrs of exposure, and the cell viability of > 80% was observed for all the concentrations (1–100 μg/mL) of nanogels. However, high concentrations demonstrated viability loss due to the toxicity effect of NH3+ ions binding to negatively charged cell membranes. The experimental results from this study offer counseling for designing and developing CS-based nanogels for the diversity of applications in the biomedical and pharmaceutical industries.

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