Abstract
pH-responsive DNA motifs have attracted substantial attention attributed to their high designability and versatility of DNA chemistry. Such DNA motifs typically exploit DNA secondary structures that exhibit pH response properties because of the presence of specific protonation sites. In this review, we briefly summarized second structure-based pH-responsive DNA motifs, including triplex DNA, i-motif, and A+-C mismatch base pair-based DNA devices. Finally, the challenges and prospects of pH-responsive DNA motifs are also discussed.
Highlights
Deoxyribonucleic acid (DNA), as the main carrier of genetic information for living organisms, has been widely studied (Zhang and Seelig, 2011; Lu et al, 2013)
We mainly described the pH-dependent DNA structures including triplex DNA, i-motif, and A+-C mismatched DNA structures and their applications in biosensor, living cells imaging, and accurate regulation of the pH response range
We summarized the recent research on pHresponsive DNA motifs, including triplex DNA, i-motif, and A+-C mismatch base pair-based DNA structures
Summary
Deoxyribonucleic acid (DNA), as the main carrier of genetic information for living organisms, has been widely studied (Zhang and Seelig, 2011; Lu et al, 2013). Because of its thermodynamic programmability, high structural features, facile synthesis, and possible conjugation to a host of molecules and nanodevices, DNA has presented an impressive potential to engineer a variety of molecular devices with applications ranging from molecular sensors to therapeutic tools (Ablasser, 2021; Kremarová et al, 2021) Thanks to those crucial properties, the functionalized DNA devices have been studied. By taking advantage of the high designability and the versatility of DNA chemistry, several groups have recently developed pH-dependent DNA-based nanodevices (Fu et al, 2019) Such functionalized DNA devices typically exploit DNA secondary structures that display pH dependence because of the presence of specific protonation sites. These further studies could confirm the power of DNA nanotechnology in biology, material science, chemistry, and physics
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