Abstract
The active center of Cd(II) carboxypeptidase A has been examined by means of perturbed angular correlation of gamma rays as a function of pH. This method simultaneously detects changes in coordination geometry, in the charge of groups within 5 Å of the metal nucleus and delineates multiple states of the active center. Carboxypeptidase A crystals exhibit one predominant state while several are present in solution. Interpretation of the experimental data in terms of Angular Overlap Theory suggests the species characteristic of the crystals has a distorted tetrahedral coordination geometry and is in equilibrium with a pentacoordinated species in solution.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
