Abstract
1. 1. Effects of benzodiazepines on the learning of psychomotor tasks in normal subjects with high neuroticism level were examined at the late stage of learning process. 2. 2. Twelve high-neurotic (HN) and 12 low-neurotic (LN) male volunteer subjects received either 5 mg diazepam, 10 mg clobazam or placebo in three treatment conditions using a double-blind method. The treatment order was counter-balanced. 3. 3. Subjects were allowed to practice 9 times on both the choice-reaction-time test (CRTT) and the mirror-drawing test (MDT) before entering the experimental sessions. 4. 4. While under placebo condition there was no difference between HN and LN subjects, HN subjects significantly lowered the CRTT performance than LN subjects under both diazepam and clobazam conditions. 5. 5. Impairment, rather than beneficial, effects of diazepam and clobazam on the CRTT performance were demonstrated in HN subjects.
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