Abstract
The exclusively old world genus Ferula belongs to the family Umbelliferae with about 130 species distributed throughout the Mediterranean area and central Asia, specially in the former USSR and neighboring countries such as Iran. In spite of many phytochemical investigations carried out on Ferula, there are only a few reports about polar secondary metabolites of this genus. On the other hand, some species of Ferula have been used in traditional medicine. Therefore, identification of polar compounds of this genus, especially of medicinal species, can be worthwhile. Up to now, various secondary metabolites including sesquiterpenes [1], sesquiterpene coumarins [2], flavonoids and sulphur containing compounds [3] have been reported from Ferula persica. In present work, we wish to report four new sesquiterpene coumarin glycosides, named persicaoside A-D, together with other known compounds. The structures of these compounds were elucidated by extensive spectroscopic methods including 1D-(1H and 13C) and 2D-NMR experiments (DQF-COSY, HSQC, HMBC, and ROESY) as well as CI-MS analysis.
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