Abstract
Effects of peroxynitrite (ONOO −), its stable product 3-nitrotyrosine (NT) and sodium nitroprusside (SNP) on isolated rat anococcygeus muscle were investigated. Administration of 0.1–1.0 mM ONOO − or 0.01–100.0 μM SNP produced concentration-dependent relaxations on the phenylephrine (2 μM)-precontracted muscle. Time courses of these relaxations to ONOO − and SNP were not similar and decomposed ONOO − caused a biphasic response composed of an initial contraction followed by a relaxation. NT (0.01–0.1 mM) either incubated for 20 min prior to precontraction or given during precontraction plateau did not attenuate precontraction or ONOO −-induced relaxations. Results of the present study demonstrate that ONOO − relaxes rat anococcygeus muscle specifically while its stable metabolite NT has no effect.
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