Abstract
Peroxisomes: A New Hub for Metabolic Engineering in Yeast.
Highlights
Specialty section: This article was submitted to Synthetic Biology, a section of the journal Frontiers in Bioengineering and Biotechnology
In the Madagascar periwinkle (Catharanthus roseus), the monoterpene indole alkaloid (MIA) pathway biosynthetizing the prominent cytotoxic compounds vincristine/vinblastine displays a highly sophisticated cellular and subcellular compartmentalization, with at least three cell types and five distinct subcellular compartments, which directly contributes to the tight regulation of the pathway (Courdavault et al, 2014; Guirimand et al, 2020a)
Other organisms adopt a simpler compartmentalization, such as the mold Penicillium chrysogenum, where the two last reactions of the penicillin pathway take place in the peroxisome (Kistler and Broz, 2015), the importance of which was demonstrated in penicillinproducing yeast Hansenula polymorpha (Gidijala et al, 2009)
Summary
Specialty section: This article was submitted to Synthetic Biology, a section of the journal Frontiers in Bioengineering and Biotechnology. Given the intense competition with endogenous and heterologous pathways, the GPP supply was determined as the main limitation (Ignea et al, 2019).
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