Abstract
The permeability properties of rat iridial vessels were examined using fluorescein angiography combined with light and electron microscopic marker studies. Results show that while control iridial vessels of some young rats are permeable to fluorescein, a marked permeability to this dye is commonly seen in older animals. Following paracentesis there is a marked increase in permeability of the radially arranged iridial vessels of older animals to fluorescein while angiograms on the younger animals were inconclusive. When carbon is injected intravenously following completion of the angiography study, both light and electron microscopic observations show that iridial vessels of control eyes are impermeable to carbon. However, following paracentesis an inflammatory reaction occurs. Carbon is seen leaving the lumen of iridial vessels in enlarged spaces between adjacent endothelial cells. This inflammatory reaction is age-related; the increase in permeability to carbon is greatest in older animals. There is little or no carbon labeling in the choroid or ciliary body of these experimental eyes. Thus, in the rat, paracentesis causes a breakdown in the blood-aqueous barrier by specifically inducing an inflammatory reaction in iridial blood vessels. This inflammatory reaction is age-related.
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