Abstract
Purpose:This study aimed to measure the peripapillary retinal nerve fiber layer (RNFL) thickness using spectral-domain optical coherence tomography (SD-OCT) in normal Iranian children aged below 18 years.Methods:Peripapillary RNFL imaging was performed in the right eye of normal Iranian children aged below 18 years using Spectralis SD-OCT (Heidelberg Engineering; Vista, CA). The effects of age, gender, cup-to-disc ratio, and spherical equivalent (SE) on global and sectoral RNFL thicknesses were evaluated.Results:A total of 115 eyes were imaged. Approximately 51 (44.3%) of the cases were female children. The mean age was 12.44 ± 2.52 years. The SE of refractive error was 0.39 ± 1.38 diopters (range: −3.00 to +4.5 D). The RNFL thickness measurements in the superior, inferior, nasal, and temporal quadrants were 129.25 ± 14.52, 128.16 ± 13.46, 76.76 ± 10.58, and 69.58 ± 9.94 μm, respectively. The global RNFL thickness was 101.01 ± 7.74 μm. In both univariate and multiple regression analyses, SE was the only determinant of RNFL thickness (all P values < 0.05).Conclusion:OCT analysis can effectively measure RNFL thickness in children, and SE is the only determinant of RNFL thickness in normal Iranian patients aged below 18 years.
Highlights
Children with suspected disc appearance are frequently referred to glaucoma clinics for optic nerve assessment and ruling out glaucoma
Since the normative database of OCT machines for retinal nerve fiber layer (RNFL) thickness does not include the measurements of children aged below 18 years, we conducted this study to measure the peripapillary RNFL thickness in normal Iranian children using Spectralis spectral domain OCT
The results of this study will serve as a basis for future evaluation of optic nerve diseases and RNFL in this age group
Summary
Children with suspected disc appearance are frequently referred to glaucoma clinics for optic nerve assessment and ruling out glaucoma. Spectral domain optical coherence tomography (SD‐OCT) is a reproducible and reliable method of measuring RNFL and has been proven to be suitable for following up the patients over time.[1,2,3] Some studies have shown that OCT is a useful tool for.
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