Abstract
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are therapeutic options for the treatment of intra-abdominal neoplasms.Following the resection ofall visible tumor areas by CRS, microscopic tumor areas are treated with HIPEC. This procedure increases the quality of life and survival. The CRS with HIPEC is acomplex surgical procedure in which the mainly younger and often otherwise healthy patientsundergo several pathophysiological changes during the operation. The main concern of the anesthesiologist is the massive volume loss, volume shift and metabolic alterations. Patients with ahigh comorbidity should undergo preoperative optimization to reduce the perioperative morbidity and mortality especially by protracted interventions.
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