Abstract
In a differential equation model of the molecular network governing cell growth and division, cell cycle phases and transitions through checkpoints are associated with certain bifurcations of the underlying vector field. If the cell cycle is driven by another rhythmic process, interactions between forcing and bifurcations lead to emergent orbits and oscillations. In this paper, by varying the amplitude and frequency of forcing of the synthesis rates of regulatory proteins and the mass growth rate in a minimal model of the eukaryotic cell cycle, we study changes of the probability distributions of interdivision time and mass at division. By computing numerically the Lyapunov exponent of the model, we show that the splitting of probability distributions is associated with mode-locked solutions. We also introduce a simple, integrate-and-fire model to analyze mode locking in the cell cycle.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
