Abstract
The developmental origins of health and disease hypothesis suggests that the conditions for the development of the organism in the prenatal and early postnatal periods thus affect the expression of genes that program the early onset of cardiovascular and metabolic diseases. Experimental studies demonstrate the major role of epigenetic mechanisms (gene methylation) in this scenario. The review provides data showing that perinatal programming can accelerate aging processes, resulting in early onset of these diseases. It considers the importance of fetal hypoxia as a factor leading to the birth of babies at increased risk for abnormalities of the brain, heart, liver, and kidney, as well as for hypertension and metabolic disorders in later life. The role of oxidative stress and reactive oxygen species in the processes of perinatal programming is discussed.
Highlights
The developmental origins of health and disease hypothesis suggests that the conditions for the development of the organism in the prenatal and early postnatal periods affect the expression of genes that program the early onset of cardiovascular and metabolic diseases
Experimental studies demonstrate the major role of epigenetic mechanisms in this scenario
The review provides data showing that perinatal programming can accelerate aging processes, resulting in early onset of these diseases
Summary
Гипотеза «программирования состояний здоровья и болезней, связанных с развитием» предполагает, что условия развития организма во внутриутробном и раннем постнатальном периодах таким образом влияют на экспрессию генов, что «программируют» раннее появление сердечно-сосудистых и метаболических заболеваний. The review provides data showing that perinatal programming can accelerate aging processes, resulting in early onset of these diseases. Гипотеза «программирования состояний здоровья и болезней, связанных с развитием», ставшая популярной в современной науке, предполагает, что условия питания и роста организма во внутриутробном и постнатальном периодах существенно влияют на структуру и функции многих органов и определяют качество здоровья индивидуума в течение последующей жизни [1, 2]. РОССИЙСКИЙ ВЕСТНИК ПЕРИНАТОЛОГИИ И ПЕДИАТРИИ, 2017; 62:(1) ROSSIYSKIY VESTNIK PERINATOLOGII I PEDIATRII, 2017; 62:(1)
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