Abstract
PURPOSE: We investigated interaction of perilipin protein and intramuscular triglyceride on expression of PPARβ/δin rat skeletal muscle.<BR> METHOD: A total of thirty-six male Sprague-Dawley were used in the study. Rats were divide into three groups: control (n=12), fasted (n=12), aerobic exercise (n=12). Aerobic exercise consist of 2-h (30 min × 4 cycle) swimming exercise and fasting included 18-h with only water. We determined intramuscular triglyceride (IMTG) content, perilipin (PLIN3, PLIN5) and PPARβ/δprotein expression, citrate synthase (CS), β-hydroxyacyl-CoA dehydrogenase (β-HAD) activity.<BR> RESULTS: Our analyses indicate that acute aerobic exercise and fasting unaltered IMTG content both soleus and white gastrocnemius muscle. Skeletal muscle PLIN3, PLIN5, PPARβ/δexhibited a less response to experimental conditions. CS and β-HAD activity remained unaffected.<BR> CONCLUSIONS: These data indicate that exercise stimulus insufficient to improved lipid metabolic capacity. The metabolic health benefits of exercise training to be fully elucidated in older and clinical populations.
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