Abstract
To assess perfusion patterns and dynamics in diabetic nephropathy (DN) rhesus monkeys of renal parenchyma by using contrast-enhanced ultrasound (CEUS). Ten rhesus monkeys were included in this study. The contrast agent was applied respectively in ten rhesus monkeys by intravenous bolus injection. The time-intensity curve was used to obtain flow-related parameters such as area under curve (AUC), time from peak to one half (HPT), intensity peak (PI), time to peak (TTP) and rise time (RT). Compared with normal control group, lesion group AUC, HPT and PI decreased significantly, and time to peak (TTP) delayed slightly. Analyzed RT in two groups, there was no significant difference. We found when blood biochemical indicators of renal function were no obvious abnormal findings, the perfusion indexes are more sensitive and dependent in early diagnosis of DN. AUC, HPT and PI might be useful in diagnostic predicting the hemodynamic changes of renal parenchyma.
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