Abstract
3192 Background: Introducing photodynamic therapy (PDT) into routine clinical use will require a radical change in excitation source, and a better understanding of photosensitizer dosimetry and biological effect. Light Sciences Corporation (LSC) has designed a Light Infusion Therapy system (Litx), based on inexpensive light-emitting diode technology and the photosensitizer talaprofin sodium (LS11). One of the advantages to interstitial PDT with the system is the potential to treat patients with large tumors by simultaneous illumination using multiple light sources. Methods: WAG/Rij rat rhabdomyosarcomas were employed to assess the feasibility and safety of multiple light source (LS) treatments. Previous to the multiple LS studies, a series of single LS light dose escalation studies (5 to 40 mW/cm, 50 to 1000 J/cm) were performed using the same model. In the multiple LS studies, each tumor-bearing rat was given 5.0 mg/kg (iv) talaporfin sodium 90 minutes prior to illumination. Tumors were grown to a size s...
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