Abstract

The synthesis of the (76–93) fragment of a lysozyme analogue was achieved using a fragment condensation approach employing the protected subfragments (76–79), (80–86), and (87–93). The utility of Bates' reagent in conjunction with N-hydroxysuccinimidc was examined for the linking of fragments. The resulting protected peptide (76–93) was found to be one of the most insoluble encountered in this whole programme directed towards the synthesis of a lysozyme analogue.

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