Abstract
The new Energypolis campus brings together the skills of EPFL Valais-Wallis, HES-SO Valais-Wallis, and the Ark Foundation's services. Together these partners respond to today's major concerns in the domains of energy, health, and the environment cutting-edge technology. The spirit of this new campus is to foster innovation in these disciplines and emulate the creation of start-up companies. The HES-SO hosts the School of Engineering (HEI) at this campus, which includes the following degree programmes: Life Technologies, Systems Engineering and Energy and Environmental Engineering, as well as their corresponding applied research institutes. Peptide technologies belong to the many activities that are carrying out in the Institute of Life Technologies. The present review summarizes the peptide technologies that are currently under development, that is, the regioselective labeling of therapeutic antibodies for cancer imaging, the development of peptide antivirals and antimicrobials for the treatment of infectious diseases, targeting of drugs conjugated to peptidic scaffolds as well as engineering of biomaterials.
Highlights
The new Energypolis campus brings together the skills of EPFL Valais-Wallis, HES-SO Valais-Wallis, and the Ark Foundation’s services
The present review summarizes the peptide technologies that are currently under development, that is, the regioselective labeling of therapeutic antibodies for cancer imaging, the development of peptide antivirals and antimicrobials for the treatment of infectious diseases, targeting of drugs conjugated to peptidic scaffolds as well as engineering of biomaterials
Trafficking of the antibody and tumor accumulation is visualized by Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) directly at the clinic.[3]
Summary
In a collaboration between Debiopharm Research & Manufacturing, the CHUV, and the HES-SO Valais-Wallis, a novel methodology was developed to regioselectively label therapeutic antibodies with an imaging cargo. Upon mixing of the antibody with the peptide reactive conjugate, the imaging cargo is attached regioselectively to the antibody Fc domain. Because the Fc domain is conserved in IgG immunoglobulins and because the conjugation reaction occurs regioselectively at this site, labeling does not compromise binding of the therapeutic antibody to its cognate antigen. The technology can be expanded to broader applications such as the preclinical evaluation of multiple pharmacodynamic and pharmacokinetic parameters of antibody candidates, the synthesis of antibody drug conjugates (ADCs),[6] and more generally to the regioselective labeling of any biological target. 2. Targeting Conserved Viral Fusion and Replication Mechanisms with Peptide Antivirals. Peptide Chemistry in Switzerland highly conserved protein–protein interactions involved in the mechanisms of viral cell entry and replication
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