Abstract
This review describes the properties and activities of lipopeptides and peptide hormones and how the lipidation of peptide hormones could potentially produce therapeutic agents combating some of the most prevalent diseases and conditions. The self‐assembly of these types of molecules is outlined, and how this can impact on bioactivity. Peptide hormones specific to the uptake of food and produced in the gastrointestinal tract are discussed in detail. The advantages of lipidated peptide hormones over natural peptide hormones are summarised, in terms of stability and renal clearance, with potential application as therapeutic agents. © 2017 The Authors Journal of Peptide Science published by European Peptide Society and John Wiley & Sons Ltd.
Highlights
Special Issue ReviewMany self-assembling molecules are amphiphilic, meaning they have both hydrophobic and hydrophilic character
25 Hamley IW, Kirkham S, Dehsorkhi A, Castelletto V, Reza M, Ruokolainen J
Lipidation is a useful tool to reduce the degradation of a drug, or to extend half-life, with some of these effects probably being the result of self-assembly, much more work is needed to investigate the possibly of many lipidated peptide drugs
Summary
Many self-assembling molecules are amphiphilic, meaning they have both hydrophobic and hydrophilic character They generally self-assemble above a critical concentration, known as the critical aggregation concentration (CAC). Amphiphilic molecules associate through non-covalent interactions to form ordered assemblies of different sizes, from nanometres to microns [3] These selfassembled structures include spherical and worm-like micelles, vesicles, fibrils and nanotubes (Figure 1). His current work is on the self-assembly of lipopeptides and incorporating them within gel networks. Hamley is Diamond Professor of Physical Chemistry at the University of Reading He has more than 20 years’ experience of research on different types of soft materials, including peptides, polymers, liquid crystals and surfactants.
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