Abstract
AbstractWe have previously shown that pentoxifylline (PTF) improves survival in an animal model of hemorrhagic shock. This paper reports upon physiologic effects of PTF in this model which might be responsible for its benefit. In a standardized model of hemorrhagic shock and resuscitation in rats, the effects of PTF added to resuscitation upon blood pressure, cardiac output, tissue oxygenation, and total body oxygen consumption were compared to placebo controls. In addition, the effects of PTF resuscitation upon polymorphonuclear leukocyte (PMN) adhesiveness was measured. PTF had no effect upon blood pressure or cardiac output. However, tissue oxygenation and oxygen consumption were increased with PTF resuscitation. PTF resuscitation also significantly decreased PMN adhesiveness. These data show that PTF improves tissue oxygenation and oxygen consumption following hemorrhage, and that this effect is not due to increased cardiac output. It must therefore be due to improved microcirculatory blood flow and tissue utilization of oxygen. This effect may be due to decreased PMN adhesiveness induced by PTF resuscitation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
