Abstract
ABSTRACTThe role of exercise as a strategy for prevention, management and therapy in cardiovascular disease has been well described, but in some studies, it has been suggested that there is an increase in biomarkers in cardiac damage or cardiac troponin (cTn) after intensive, high-intensity exercise in healthy individuals. Several studies have shown significant increases in cardiac troponins after different types of exercise. The latest meta-analysis, showing that high-sensitivity cardiac troponin (hs-cTn) increases in about 83% of individuals after long and intensive exercise. The current pathophysiology of hs-cTn is not well understood. Several hypotheses have been proposed, such as transmembrane leakage from cytoplasmic free cTnT and cTnI or decreased troponin clearance from plasma, both caused by overloading of free radicals, myocardial stretching, elevated core temperature, or alteration of pH. Further research is needed with a full prospective study to evaluate the underlying pathophysiology of enhancing high sentivity cardiac troponin (hs-cTn) is an effective strategy for preventing or limiting cardiac injury and sport exercise safe for heart.Keywords: cardiac Troponin (cTn), high sensitivity cardiac troponin (hs-cTn), high intensity intensive exercise
Highlights
Pendahuluan Troponin adalah suatu kompleks protein yang ditemukan pada seluruh filamen tipis otot bergaris atau aktin
The role of exercise as a strategy for prevention, management and therapy in cardiovascular disease has been well described, but in some studies, it has been suggested that there is an increase in biomarkers in cardiac damage or cardiac troponin after intensive, high-intensity exercise in healthy individuals
Several hypotheses have been proposed, such as transmembrane leakage from cytoplasmic free cardiac Troponin T (cTnT) and cardiac Troponin I (cTnI) or decreased troponin clearance from plasma, both caused by overloading of free radicals, myocardial stretching, elevated core temperature, or alteration of pH
Summary
Kompleks troponintropomyosin mengatur kontraksi otot bergaris dan terdiri dari tiga subunit Peningkatan cTn dalam darah melebihi persentil ke-99 dari referensi normal populasi, pedoman menunjukkan bahwa CV dari uji cTn yang ideal digunakan adalah ≤ 10% pada konsentrasi persentil ke-99, maka jelas, uji cTnT generasi keempat tidak memiliki ketepatan yang memadai. Uji high sentivity cardiac troponin (hscTn) merupakan modifikasi dari uji cTnT generasi keempat 7. Troponin jantung telah menjadi komponen penting dari definisi infark miokard dan sangat diperlukan untuk deteksi dini, meskipun generasi saat ini tes high sentivity cardiac troponin (hs-cTn) tidak cocok dalam sensitivitasnya untuk mendeteksi kerusakan miokard, peningkatan hs-cTn dapat terjadi pada gangguan kardiovaskular akut atau kronis lainnya seperti gagal jantung, emboli paru, aritmia, atau gagal ginjal 9. Menunjukkan bahwa high sentivity cardiac troponin (hscTn) meningkat di atas persentil ke-99 pada sekitar 83% individu setelah latihan yang lama dan intensif. Seperti kebocoran transmembran dari cytoplasmic free cTnT dan cTnI atau penurunan clearance troponin dari plasma, keduanya disebabkan oleh kelebihan muatan radikal bebas, peregangan miokard, peningkatan suhu inti, atau perubahan dari pH 10
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