Abstract
although it has the advantage of being given orally, seems less effective, and ampicillin similarly. Comparative statistical evidence of the value of the various penicillins and of the antibiotics is not available, and would be difficult to obtain, but I have no personal doubt that at present in the acute infection methicillin and chloramphenical are the two most effective drugs. A major anxiety is the development of bacterial resistance in the child with repeated or persistent infection. This develops sooner or later in all these children and makes the continued prophylactic use of antibiotics unwise. An antibiotic free from this drawback would be of the greatest value: in about 12 children with cystic fibrosis treated for up to one year with daily fucidin I have as yet had no case of drug resistance. But this may in any case not develop with any drug given prophyllactically for a year or more. For the pseudomonas there appears to be no 'answer at present, whether the antibiotic is given by mouth, injection or by aerosol.
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