Abstract
Tablet dosage form is one of the most widely used pharmaceutical. Acetyl salicylic acid is an anti inflammatory medicine, active substance not heat resistant. Starch as a binder of materials in the manufacture of tablets are hydrophilic because amylopectin starch can absorb most of the water. This study aims to determine the variation of the concentration of starch banana heart of stone as the material of binder on physico-chemical properties acid tablets acetyl salicylic meet the requirements of the Indonesian Pharmacopoeia. Based on the explanation above, the research conducted to make four concentration of the starch of banana, i.e. FI (5%), FII (10%), FIII (12.5%) and FIV (15%). From the results evaluation obtained include : flow time, steep angle, indication index, uniformity of weight, hardness, fragility and crumbling time of tablets, all formulas have been qualified by Pharmacopoeia Indonesia. Formulation IV after investigation had better tablet quality.
Highlights
Di era globalisasi yang serba instan ilmu pengetahuan dan teknologi berkembang secara pesat, mengharuskan bidang teknologi pada bidang farmasi selalu mengikuti perkembangan tersebut
This research was conducted to see the effect of variations in the concentration of starchy banana flower as a binder on the physical properties of acetyl salicylic acid tablets
This study aims to determine variations in the concentration of starchy banana stone as a binder to the physicochemical properties of tablets to meet the requirements of Indonesian Pharmacopoeia
Summary
Di era globalisasi yang serba instan ilmu pengetahuan dan teknologi berkembang secara pesat, mengharuskan bidang teknologi pada bidang farmasi selalu mengikuti perkembangan tersebut. Tablet merupakan salah satu sediaan farmasi yang paling banyak digunakan, karena memiliki keuntungan terkait dengan ketetapan penggunaan dosis, pengemasan secara baik, transportasinya praktis, mudah dalam pemakaian dan mempunya stabilitas yang baik selama penyimpanan (Voight, 1994). Dalam praformulasi tablet amilum dari bahan alam sebagai pengikat kering belum banyak digunakan, kebanyakan digunakan adalah bahan sintesis antara lain sukrosa, PVP, etil selulosa, starch 1500 dan lain sebagainya. Hasil penelitian menunjukkan bahwa amilum pisang mudah di isolasi dan dapat dibuat dalam bentuk serbuk atas dasar ini jantung pisang batu yang mempunya kandungan karbohidrat diolah menjadi amilum kering karena amilum merupakan Amilum adalah senyawa polisakarida yang diperoleh dari tanaman yang sering dipakai sebagai bahan tambahan dalam pembuatan tablet (Gusmayadi Inding, 2012)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
