Abstract
Chemically, pyrimethamine (Daraprim) is 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine, with the empirical formula C<sub>12</sub>H<sub>13</sub>N<sub>4</sub>Cl. This chemical was synthesized by the Wellcome Research Laboratories, Tuckahoe, N. Y., as an antimalarial drug which arrests plasmodial development at those stages involving nuclear division. Besides this antimalarial activity, pyrimethamine has been shown to have an extraordinarily potent antimetabolite activity. To my limited knowledge, the mode of action of the preparation against toxoplasmosis has not been entirely elucidated. However, Eyles and his associate,<sup>1</sup>in 1952, reported antitoxoplasminic action of the drug in mice and, in 1953, showed that pyrimethamine and sulfadiazine were synergistic to each other against experimental toxoplasmosis in the mouse.<sup>2</sup>Since these reports, the drug has been widely used in the treatment of presumptive toxoplasmic infections of man as well as of experimental toxoplasmosis of animals. In the past years, numerous papers on the subject have been published, creating
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
