Abstract
PEGylation is an industrial commonly used approach for improving the biodistribution of drugs and biomolecules within the human body. Indeed it helps to improve systemic circulation time and decreases immunogenicity. While the impact of PEG coatings on the fate of systemically administered nanoparticle formulations has been widely studied, their role in modifying drug delivery, to the best of our knowledge, has never been addressed directly. Here we studied the influence of different PEGylation strategies in colloids drug loading and then on mass transport performances (i.e. drug delivery kinetics). Coatings were prepared using PEG monomethyl ether (mPEG), modifying its terminal hydroxyl groups with different linkers: imidazole and carboxyl terminal groups. Mass transport experiments showed that taking advantage of drug-polymer interactions it is possible to tune drug loading within colloids and their consequent release. This outcome could be considered a promising perspective of nanogels use as carriers for drug delivery, improving their therapeutic effect through polymer surface modifications.
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