Abstract
Current progress in nanotechnology provides a new hope for the substantial development in the success of cancer therapy particularly in controlling tumor growth and development. PEGylated citric acid dendrimers are biocompatible compounds being developed with an aim to target the myeloid cells, from which leukemia starts and spreads. Developed dendrimers also overcome the limitations observed with usual cancer therapies like drug leakage during circulation and short circulation time in blood. Cytarabine, an antimetabolite antineoplastic agent was tightly encapsulated within the dendrimer through simple complexation and targeted to tumor cells by way of high affinity interactions. PEGylation prevents the drug leakage during circulation, bypasses RES uptake by opsonins and improves drugs stability, circulation time when administered. In present study, PEGylated citric acid dendrimers were synthesized using Divergent technique and loaded with Cytarabine. Synthesized dendrimers were evaluated for different parameters like SEM, DSC, NMR, % drug entrapment and in-vitro drug release studies etc.
Highlights
Nanotechnology has prompted an outstanding convention of different fields like physical sciences, applied physics, biology, optics, computational investigation and modeling and materials science
Acute myeloid leukemia is a cancer of bone marrow and blood, characterized by rapid and abnormal growth of white blood cells that accumulates in the bone marrow and further interfere with the production of normal blood cells
Absence of signals at 8.8-8.5 ppm indicates that acidic groups of citric acid dendrimers have been interacted with the drug molecules
Summary
Nanotechnology has prompted an outstanding convention of different fields like physical sciences, applied physics, biology, optics, computational investigation and modeling and materials science. Dendrimers, nanosized spheroid structures capable of carrying drug molecules encapsulated within its interior void spaces or attached to its external terminal groups (Shishu and Maheswari, 2009) They are made with a level of control, which is not possible with most linear polymers, resulting in a monodispersed, globular macromolecule with many peripheral groups. Considerable progress has been made concerning use of dendrimers in the diagnosis and treatment of cancer including the delivery of antitumor agent and contrasting agents to the target tumor cells, photodynamic therapy, boron-neutron capture therapy, photothermal therapy etc (Inoue, 2000; Agarwal and Kulkarni, 2015). Diagnosis of tumor cells using MRI contrast agents will be progressed with the inclusion of dendrimers as contrast agents These novel contrast agents target the cancer cells (Rao et al, 2013). An attempt was made to design and deliver Cytarabine loaded PEGylated citric acid dendrimers to the tumor cells and examine its influence on the invitro drug release, %entrapment efficiency studies etc
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