Abstract
62 Zervamicins isolated from the fungus Emericellopsis salmosynnemata belong to the peptaibols family. They consist of 15 amino acid residues and C-terminal moiety of the amino alcohol phenylalaninol. Primary structures of zervamicins IIA and IIB (Zrv-IIA and Zrv-IIB) differ in only one amino acid residue at position 4 ( α -aminoisobutyric acid in Zrv-IIA and D -isovaline in Zrv-IIB) [1, 2]. It was shown that an intraperitoneal injection of Zrv-IIA and Zrv-IIB to male Wister rats in an open-field test caused a decrease in the locomotor and exploratory activity of animals [3]. A study of neurotropic activity of male CD-1 mice in holeboard, elevated plus maze, and forced-swim tests revealed differences in the efficiency of these peptaibols [4]. To study the neurotropic effect of zervamicins in greater detail, we investigated their analgetic activity in the hot-plate test and assessed their effect on body temperature of laboratory animals. This study was performed with 6- to 8-week-old male CD-1 mice. The animals were housed under the standard conditions (light/dark cycle, 12 : 12 h; room temperature, 18‐26 ° C; humidity, 30‐70%) and received water and food ad libitum. All manipulations with animals were performed in conformity with the protocol approved by the Committee on Animal Research and Ethics of the Institute of Bioorganic
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