Abstract
Pectins are the collective name for a group of heterogeneous, high molecular weight, branched polysaccharides that are found in the cell walls of higher plants. In this study, we intend to determine the antibacterial activity of pectin against reference strains and clinical isolates of Helicobacter pylori. The results show that pectin produced antibacterial effects on all the 16 clinical isolates and 2 reference strains of H. pylori with the greatest antibacterial effect at a low pH (5.0) versus higher pHs. The lowest Minimum Inhibitory Concentration recorded was of 0.016 μg/μl. Antibiotic resistance, therapy costs, and undesirable side effects stress the need for new antimicrobials or alternative therapies. The results from our study can further our goal of future eradication of H. pylori infection using new molecules.
Highlights
Pectins are a class of complex polysaccharides found in the cell walls of higher plants
We intend to determine the antibacterial activity of pectin against reference strains and clinical isolates of Helicobacter pylori
The results show that pectin produced antibacterial effects on all the 16 clinical isolates and 2 reference strains of H. pylori with the greatest antibacterial effect at a low pH (5.0) versus higher pHs
Summary
Pectins are a class of complex polysaccharides found in the cell walls of higher plants. They contribute to the firmness and structure of plant tissue both as part of the primary cell wall and as the main component in the middle lamella, which is responsible for cell-to-cell adhesion [1]. Pectin is the collective name for a group of heterogeneous, high molecular weight, branched polysaccharides. They are composed of distinct structural domains linked together in characteristic patterns. They compromise acidic polysaccharides including homogalacturonan, rhamnogalacturonan I, rhamnogalacturonan II and neutral oligosaccharide chains such as galactans, arabinans, and arabinogalactans [2]. The most common pectin is isolated from citrus and is extensively branched
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