Abstract
Background: Phosphatidylinositol (PI) dependent kinase 1, PDK1, is a master kinase that activates other kinases important in cell growth and survival including members of the AKT, PKC, RSK and SGK families. PDK1 can interact with its substrates through both PI-dependent or PI-independent (PIF-mediated) mechanisms. SNS-510 is a potent, orally bioavailable inhibitor of active and inactive conformations of PDK1 and binds deep in the adaptive pocket. This interaction inhibits PI3K activity and perturbs the hydrophobic PIF-pocket, thereby affecting both PI-dependent and -independent pathways (Hansen Mol Cancer Ther 2015).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
