Abstract
Platelet derived growth factors (Pdgfs) play a pleiotropic role in embryo development and tissue morphogenesis. Our previous studies show that Pdgf receptor alpha (Pdgfra) is essential for midface and calvaria development in mice. In the present study, we show that Pdgfra plays an indispensible role in chondrocyte formation during craniofacial morphogenesis. Our results show Pdgfra is expressed in the chondrocyte progenitors, and inactivating Pdgfra causes chondrocranium hypoplasia. Further analysis revealed that Pdgfra mutant exhibits decreased expression of Sox9 and Col2a1, accompanied by modest change of cell proliferation rate in alcian blue positive cells. On the other hand, expressing an auto‐active form of Pdgfra (aK allele) in the whole embryo leads to ectopic cartilage formation. In addition, inactivating Pdgfra or activate Pdgfra specifically in chondrocytes causes a mild cartilage phenotype. These data indicate a role for Pdgfra in chondrocyte progenitor cell formation. In summary, our study identified Pdgfra as a novel regulator of cartilage formation, and that it regulates chondrocyte progenitor formation during embryo development.Support or Funding InformationNIDCR DE024617This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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