PD62-08 DIFFERENCES IN THE GUT MICROBIOME COMPOSITION BETWEEN MEN WITH ERECTILE DYSFUNCTION AND A MATCHED COHORT: A PILOT STUDY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Basic Research & Pathophysiology (PD62)1 Sep 2021PD62-08 DIFFERENCES IN THE GUT MICROBIOME COMPOSITION BETWEEN MEN WITH ERECTILE DYSFUNCTION AND A MATCHED COHORT: A PILOT STUDY Mahdi Osman, Farouk El-Khatib, Jeanie Nguyen, Edward Choi, Joshua Randolph, Guruduth Banavar, Ying Cai, Pedro Moura, Nan Shen, Ryan Toma, Momchilo Vuyisich, Nathalie Yafi, and Faysal Yafi Mahdi OsmanMahdi Osman More articles by this author , Farouk El-KhatibFarouk El-Khatib More articles by this author , Jeanie NguyenJeanie Nguyen More articles by this author , Edward ChoiEdward Choi More articles by this author , Joshua RandolphJoshua Randolph More articles by this author , Guruduth BanavarGuruduth Banavar More articles by this author , Ying CaiYing Cai More articles by this author , Pedro MouraPedro Moura More articles by this author , Nan ShenNan Shen More articles by this author , Ryan TomaRyan Toma More articles by this author , Momchilo VuyisichMomchilo Vuyisich More articles by this author , Nathalie YafiNathalie Yafi More articles by this author , and Faysal YafiFaysal Yafi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002099.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The gut microbiome (GM) plays an important role in human health, ranging from supplying essential nutrients, synthesizing vitamin K, to promoting angiogenesis and enteric nerve function. It has also been recently associated with a variety of chronic health conditions. To date, however, there have been no studies that have attempted to establish any association between the GM and erectile dysfunction (ED). As such, we sought to analyze stool samples from patients with ED and compare them to matched controls for differences in their GM. METHODS: We collected stool samples from 37 patients with ED and matched them with 37 controls. All samples were processed by a third-party company, Viome Inc. The samples were analyzed by metatranscriptome sequencing which allows for data to show both the taxonomy of the microbiome and its KEGG orthology (KO). We compared richness, prevalence and expression of the taxa and KOs between the ED and control groups. RESULTS: There were 224 species (16.85%) with significantly differential prevalence and 135 species (10.31%) with significantly differential expression. There were 565 KOs (10.42%) with significantly differential prevalence and 653 KOs (12.05%) with significantly differential expression. Richness is the number of microbial species detected in a sample. Diversity assesses the abundance and evenness of a species to assess how diverse an individual sample is. The ED group demonstrated significantly lower taxonomic richness and diversity, p= 1.33 x 10^-5 (see figure below). CONCLUSIONS: This is the first study to look at associations between the GM and ED. Patients with ED have significantly lower taxonomic richness and diversity. Further analyses are needed to better understand the implications of these findings and uncover potential targets for early targeted treatment or prevention of ED. Source of Funding: microbiome analysis kits were provided by Viome, Inc © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1075-e1075 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mahdi Osman More articles by this author Farouk El-Khatib More articles by this author Jeanie Nguyen More articles by this author Edward Choi More articles by this author Joshua Randolph More articles by this author Guruduth Banavar More articles by this author Ying Cai More articles by this author Pedro Moura More articles by this author Nan Shen More articles by this author Ryan Toma More articles by this author Momchilo Vuyisich More articles by this author Nathalie Yafi More articles by this author Faysal Yafi More articles by this author Expand All Advertisement Loading ...