PD36-06 PROSPECTIVE TWO-ARM STUDY OF FERTILITY IN MEN WITH COVID-19

Abstract

You have accessJournal of UrologyCME1 May 2022PD36-06 PROSPECTIVE TWO-ARM STUDY OF FERTILITY IN MEN WITH COVID-19 Dmitry Enikeev, Mark Taratkin, Andrey Morozov, Vladislav Petov, Dmitry Korolev, Anastasia Shpikina, Leonid Spivak, Svetlana Kharlamova, Shchedrina Irina, Oleg Mestnikov, Dmitry Fiev, Timur Ganzha, Marina Geladze, Aichurok Mambetova, Evgenia Kogan, Nikolay Zharkov, Gregoriy Demyashkin, Shahrokh Shariat, and Petr Glybochko Dmitry EnikeevDmitry Enikeev More articles by this author , Mark TaratkinMark Taratkin More articles by this author , Andrey MorozovAndrey Morozov More articles by this author , Vladislav PetovVladislav Petov More articles by this author , Dmitry KorolevDmitry Korolev More articles by this author , Anastasia ShpikinaAnastasia Shpikina More articles by this author , Leonid SpivakLeonid Spivak More articles by this author , Svetlana KharlamovaSvetlana Kharlamova More articles by this author , Shchedrina IrinaShchedrina Irina More articles by this author , Oleg MestnikovOleg Mestnikov More articles by this author , Dmitry FievDmitry Fiev More articles by this author , Timur GanzhaTimur Ganzha More articles by this author , Marina GeladzeMarina Geladze More articles by this author , Aichurok MambetovaAichurok Mambetova More articles by this author , Evgenia KoganEvgenia Kogan More articles by this author , Nikolay ZharkovNikolay Zharkov More articles by this author , Gregoriy DemyashkinGregoriy Demyashkin More articles by this author , Shahrokh ShariatShahrokh Shariat More articles by this author , and Petr GlybochkoPetr Glybochko More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002594.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: COVID-19 infection is hypothesized to have a potentially negative effect on male fertility through direct damage to the testes. The current trial is aimed at investigating the effect of SARS-CoV-2 on fertility and determining if viral bodies directly damage testicular function. METHODS: This prospective study included controls comprising healthy participants and cases of patients suffering from pneumonia based on chest CT and a positive of SARS-CoV-2 throat swab exhibited only moderate symptoms in accordance with the WHO classification. Extensive epidemiological, clinical, laboratory (hormonal levels, etc.) and ultrasound data (color doppler ultrasound of the scrotum) were collected. A sperm examination was performed in cases during their COVID-19 related hospital stay and 3 months after the discharge home. We also assessed the testicles of COVID-19 patients who died of their disease (n=20) obtained during autopsies. RESULTS: A total of 88 participants were included (44 controls and 44 cases). Blood testosterone levels were below normal (local reference values, 5-50 nmol/ml) in 27.3% of the cases (12/44). The mean level (7.3±2.7 nmol/ml) was lower than that in the healthy controls (13.5±5.2 nmol/ml, p <0.001). At 3 months after discharge, the level returned to normal (13.7±4.5 nmol/ml) and was no different from that of the controls. An increase in LH and FSH was also detected compared to the healthy controls (p=0.047 and p=0.002). The spermogram revealed decreased motility in COVID-19 patients (p=0.001), and higher number of immobile sperm (during COVID-19 – 58.8% and at 3 months 47.4%, p=0.005). All these parameters returned to normal at 3 months after discharge. As for pathology findings, in the majority of autopsies (18/20) structural disorders of the testicular tissue, with signs of damage to germ cells were observed. CONCLUSIONS: COVID-19 and its treatment significantly affect hormone levels and sperm quality during the disease. Postmortem examination confirms inflammation and viral infiltration of the testicles. However, in those who had moderate to severe disease, decline in hormone levels and sperm quality was transient with values returning to baseline at 3 months. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e635 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Dmitry Enikeev More articles by this author Mark Taratkin More articles by this author Andrey Morozov More articles by this author Vladislav Petov More articles by this author Dmitry Korolev More articles by this author Anastasia Shpikina More articles by this author Leonid Spivak More articles by this author Svetlana Kharlamova More articles by this author Shchedrina Irina More articles by this author Oleg Mestnikov More articles by this author Dmitry Fiev More articles by this author Timur Ganzha More articles by this author Marina Geladze More articles by this author Aichurok Mambetova More articles by this author Evgenia Kogan More articles by this author Nikolay Zharkov More articles by this author Gregoriy Demyashkin More articles by this author Shahrokh Shariat More articles by this author Petr Glybochko More articles by this author Expand All Advertisement PDF DownloadLoading ...