PD33-04 DEVELOPMENT AND VALIDATION OF A SELF-REPORTED MEASURE FOR UNDERACTIVE BLADDER

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD33-04 DEVELOPMENT AND VALIDATION OF A SELF-REPORTED MEASURE FOR UNDERACTIVE BLADDER Elodi Dielubanza, Rebekah Zincavage, Michael Maurao, James Ambrosoli, Tamera Bavendam, and Michael O'leary Elodi DielubanzaElodi Dielubanza More articles by this author , Rebekah ZincavageRebekah Zincavage More articles by this author , Michael MauraoMichael Maurao More articles by this author , James AmbrosoliJames Ambrosoli More articles by this author , Tamera BavendamTamera Bavendam More articles by this author , and Michael O'learyMichael O'leary More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003326.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Underactive bladder (UAB) is commonly encountered but poorly defined. Though detrusor underactivity (DU) is the accepted underlying mechanism of UAB, a distinct clinical syndrome has not been described. As such, there is a delay in identifying affected individuals and effective treatments are limited. Validated self-reported symptom measures are invaluable tools for uniform and reproducible symptom assessment and are needed to better characterize this condition, efficiently identify patients, and enable innovation in treatment modalities. We describe the development and validation of a self-reported measure for UAB. METHODS: Following federal guidelines for Patient Reported Outcome Measures (PROM) development and validation, we implemented a 5-stage study design, including sequential qualitative and quantitative assessments. RESULTS: Using existing UAB literature and clinician expert opinion we developed a conceptual model for the study, consisting of five domains including symptoms (e.g. storage, voiding, post-voiding) and impacts (e.g. activities of daily life, burden, quality of life). Phase I focused on concept elicitation and symptom identification through the use of qualitative focus groups and phone interviews. Data collected during the focus groups informed the development of the concept elicitation interview guide. Patients with urodynamic DU were identified and concept elicitation interviews were performed to identify condition specific symptoms, determine the language used by individuals to describe their symptoms and to assess symptom prevalence. Using this data, we created a draft self-administered multidimensional risk assessment questionnaire, containing 34 questions. A separate sample of patients with and without DU were utilized to perform cognitive debriefing of the instrument to assess comprehension, face validity and content validity. A revised questionnaire was created and subjected to psychometric validation with a 3rd cohort of both urological patients and healthy controls. A quantitative scoring algorithm was also developed. CONCLUSIONS: The final instrument is a 14 item self-reported measure focused on symptoms and quality of life, designed to be consistent with Lower Urinary Tract Dysfunction Research Network Comprehensive Assessment of Self Reported Urinary Symptoms. It is designed to be completed in 5-10 minutes. Most questions are on a 5 point rating scale with a recall period of one week. Source of Funding: NIH Grant: 1U01DK110377 © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e914 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Elodi Dielubanza More articles by this author Rebekah Zincavage More articles by this author Michael Maurao More articles by this author James Ambrosoli More articles by this author Tamera Bavendam More articles by this author Michael O'leary More articles by this author Expand All Advertisement PDF downloadLoading ...