PD26-08 IMPROVED TISSUE YIELD AND PROSTATE CANCER DETECTION OF A NOVEL BIOPSY PRESERVATION SYSTEM

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening VI1 Apr 2016PD26-08 IMPROVED TISSUE YIELD AND PROSTATE CANCER DETECTION OF A NOVEL BIOPSY PRESERVATION SYSTEM Michael Cohen, Boris Yudkevich, Helena Yodko, and Irit Elmalah Michael CohenMichael Cohen More articles by this author , Boris YudkevichBoris Yudkevich More articles by this author , Helena YodkoHelena Yodko More articles by this author , and Irit ElmalahIrit Elmalah More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.369AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Current handling of prostate biopsy cores has many flaws. Fragmentation, loss of orientation and length reduction are just few factors that may reduce cancer detection or obscure the tumor location. The SmartBxTM(SBx)(UC-care medical system) offers a semi-automated download of cores, while preserving its configuration and orientation as on the needle, onto a designated cassette which then goes a routine pathology lab processing. Our objectives were to assess this system against a routine download in maintaining tissue length and integrity, and examine its effect on cancer detection. METHODS Patients having a routine prostate biopsy (12-20 core, Bard® Magnum Biopsy gun, 18G needle) were consented for a random comparison between standard (Std.) download (i.e. into formalin vial) and the SBx download. Differences in core length and integrity were documented by camera. The core initial length was measured on the open needle, then, after processing, paraffin embedding and H&E staining,- on the glass slide. Cancer detection per biopsy core was checked for both methods. RESULTS A total of 3412 cores were taken from 376 Patients (Std.- 1768, SBx- 1653). The final core length was 10±5.8 mm using the Std. method vs. 12.4±3.7 mm using the SBx. The relative reduction in core length (i.e. vs. the initial, on the needle, 100%) was 62±17 % Vs.78±19 % respectively. Corresponding with this 24% relative increase (P <0.01) in core length, a 25% increase in cancer detection rate (10.7% vs. 13.3% per core, P<0.05) was observed for 216 patients with PSA<10, who had a 12 cores procedure. The SBx. kept core configuration and orientation, including fragments [Pic. A1-2]. CONCLUSIONS The use of the semi-automated SBx. download system led to an increased final cores length and cancer detection rate per core,- a linkage previously suggested, in tissues handled manually. Keeping cores orientation and configuration as seen on the biopsy needle allows a within-core cancer localization and, if integrated with new image guided- TRUS biopsy systems [Pic. A3], may offer a precise within-prostate cancer localization. This may have an important role in managing repeated biopsies, active surveillance and improve accurate planning of focal treatment of prostate cancer [Pic. A4]. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e647 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Michael Cohen More articles by this author Boris Yudkevich More articles by this author Helena Yodko More articles by this author Irit Elmalah More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...